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Sibutramine hydrochloride monohydrate – Sibutramine HCl

Sibutramine, usually available as sibutramine hydrochloride monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant. Sibutramine HCl is a neurotransmitter reuptake inhibitor that reduces the reuptake of serotonin (by 53%), norepinephrine (by 54%), and dopamine (by 16%), thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to influence appetite. Older anorectic agents such as amphetamine and fenfluramine force the release of these neurotransmitters rather than affecting their reuptake.

Sibutramine Hydrochloride Monohydrate Indications:

Cardiac valve dysfunction and primary pulmonary hypertension have been associated with the use of centrally acting appetite suppressants. Sibutramine does not promote the release of serotonin (5-hydroxytryptamine, 5-HT) from nerve terminals as do the appetite suppressants that were associated with these adverse events most commonly. A comparison of echocardiograms performed on patients after 0.5 to 16 months (mean 7.6 months) of treatment with 15 mg per day of sibutramine (132 patients) or placebo (77 patients) showed no difference in the incidence of valvular heart disease between the two groups. A second study in 25 patients comparing echocardiograms administered at baseline with those administered after 3 months of treatment with 5 to 30 mg per day of sibutramine detected no cases of valvular heart disease.

In two 12-month studies of sibutramine in obese subjects, maximum weight loss was achieved by 6 months and statistically significant weight loss was maintained over 12 months. Among patients receiving 15 mg per day of sibutramine in clinical weight-loss trials, more than 50% lost ³ 5% of their baseline body weight and about 25% lost ³ 10% of their baseline body weight. However, some weight was regained after discontinuation of sibutramine.

Sibutramine HCl is indicated for the management of obesity, including weight loss and maintenance of weight loss, in patients on a reduced-calorie diet. Sibutramine should be used only in obese patients with an initial body mass index ³ 30 kg of body weight per square meter of height (kg/m 2) or with an initial body mass index ³ 27 kg/m 2 in the presence of other risk factors, such as hypertension, diabetes, or dyslipidemia. Safety and efficacy of sibutramine use for more than 1 year have not been evaluated in controlled trials.

This medicine contains the active ingredient sibutramine hydrochloride monohydrate, which is a type of anti-obesity medicine. In Europe the drug name is Reductil, in US is called Meridia. Recently it is classified as a Schedule IV controlled substance in the United States.

It is in a class of medications called appetite suppressants. It works by acting on appetite control centers in the brain to decrease appetite. No metter on brand name, Sibutramine HCl comes as a capsule to take by mouth.

You will probably lose weight soon after you begin taking sibutramine and following your diet and exercise program. Be sure to monitor your weight, and call your doctor if you do not lose at least 4 pounds during your first 4 weeks of therapy. Your doctor may wish to change your dose of sibutramine.

You may not continue to lose weight after your first 6 months of treatment. However, you should continue to take it even if you have stopped losing weight. If you stop taking sibutramine, you may gain weight. Do not stop taking sibutramine without talking to your doctor.

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Reductil (sibutramine) – Slimming and Diet Pill

People can rely on prescription pills, which are specifically designed to treat their obesity problems. Among these prescription slimming pills, Sibutramine is quite noteworthy, as it works to both manage weight and control obesity. Sibutramine acts as a slimming pill as well as a diet pill.

Abbott Laboratories manufactures Sibutramine slimming pills. These diet pills are available in licensed pharmacies in many countries of the world including the European Union. These slimming pills are also available on prescription in the UK.

Medical tests on Sibutramine and its success rates

Some medical tests, which were conducted to test the effectiveness of Sibutramine, have confirmed its usefulness in controlling obesity. Read about one of the medical tests of Sibutramine.

· The first phase of Sibutramine test was conducted on patients who were split into two groups and given Sibutramine and placebo respectively. These patients were closely monitored for a period of 12 months. The results of this trial showed that patients who took Sibutramine experienced weight loss of 5.2kg compared to 0.5kg weight loss by those who took placebo

· The second phase was conducted on patients who had already lost about 2 percent of their initial body weight after 4 weeks of treatment. One group was continued with Sibutramine and the other was given placebo for another 48 weeks. The results showed that the Sibutramine group showed about 4 percent decrease in weight loss compared to the other group on placebo, which showed 0.2 percent weight gain

· The final phase was conducted on patients who showed about 5 percent of weight loss after continuous treatment of Sibutramine for six months. The results showed that these patients maintained lost weight. They did not regain the weight as compared to those who took placebo and showed weight gain

Ingredient and Strengths of Sibutramine

Sibutramine is available in tablet form in strengths of 10mg and 15mg. You should take only the recommended dosage by your GP, as it is the best dosage to suit you. Sibutramine hydrochloride is the main ingredient in a Sibutramine slimming pill. It works by preventing two neurotransmitters known as noradrenaline and serotonin from attaching to nerve cells in the brain. These two neurotransmitters influence processes in the brain and can alter your mood. Neurotransmitters are natural chemicals in the brain that transmit messages between nerve cells.

The regular dosages of Sibutramine help increase the amount of these two neurotransmitters and they act freely in the brain. Consequently, the users may have feelings of fullness even if they eat less food.

Side effects of Sibutramine

The common side effects of Sibutramine are headache, increased sweating, increased heart rate, dry mouth, insomnia, nausea, anxiety, depression, and menstrual cycle disorder in women. It also results in increase in blood pressure levels in some users. These side effects are generally mild. However, you should keep your doctor informed about their occurrence.

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Buy Sibutramine online: facts you should know

Sibutramine, usually available as sibutramine hydrochloride monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant.

Patients taking sibutramine may achieve a 5-10% reduction from their baseline weight. Additionally, sibutramine-assisted weight loss has been accompanied by improvement in blood lipids (e.g, cholesterol). Sibutramine was approved by the FDA in 1997.

Sibutramine is used in combination with a reduced calorie diet and exercise to help people who are overweight lose weight and maintain their weight loss. Sibutramine is in a class of medications called appetite suppressants. It works by acting on appetite control centers in the brain to decrease appetite.

Sibutramine is a neurotransmitter reuptake inhibitor that reduces the reuptake of serotonin (by 53%), norepinephrine (by 54%), and dopamine (by 16%), thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to influence appetite. Older anorectic agents such as amphetamine and fenfluramine force the release of these neurotransmitters rather than affecting their reuptake.

Despite having a mechanism of action similar to tricyclic antidepressants, sibutramine has failed to demonstrate antidepressant properties in animal studies. It was approved by the U.S. Food and Drug Administration (FDA) in November 1997 for the treatment of obesity.

Dosage of Sibutramine

Sibutramine is taken once daily, generally in the morning. Therapy usually is started with one 10mg tablet per day. The dose may be increased to 15mg by the physician after several weeks to achieve the desired effect. Doses of up to 60mg have been studied. Sibutramine may be taken with or without food.

Sibutramine comes as a capsule to take by mouth. It is usually taken with or without food once a day. To help you remember to take sibutramine, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sibutramine exactly as directed. Sibutramine can be habit forming. Do not take more or less of it or take it more often or for a longer time than prescribed by your doctor.

Your doctor may start you on a low dose of sibutramine and increase your dose, after you have been taking sibutramine for at least 4 weeks. Your doctor may decrease your dose if you experience certain side effects while you are taking your starting dose.

You will probably lose weight soon after you begin taking sibutramine and following your diet and exercise program. Be sure to monitor your weight, and call your doctor if you do not lose at least 4 pounds (1.8 kilograms) during your first 4 weeks of therapy. Your doctor may wish to change your dose of sibutramine.

You may not continue to lose weight after your first 6 months of treatment. However, you should continue to take sibutramine even if you have stopped losing weight. If you stop taking sibutramine, you may gain weight. Do not stop taking sibutramine without talking to your doctor.

Sibutramine Contraindications

Sibutramine is contraindicated in patients with:

* Psychiatric conditions as bulimia nervosa, anorexia nervosa, serious depression or preexisting mania
* Patients with a history of or a predisposition to drug or alcohol abuse
* Hypersensitivity to the drug
* Patients below 18 years of age
* Concomitant treatment with a MAO inhibitor, antidepressant or other centrally active drugs, particularly other anoretics
* History of peripheral arterial disease
* Hypertension that is not sufficiently controlled (e.g., > 145/90 mmHg), caution in controlled hypertension
* Existing pulmonary hypertension
* Existing damage on heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, previous myocardial infarction
* Stroke or transient ischemic attack (TIA)
* Hyperthyroidism (overactive thyroid gland)
* Closed angle glaucoma
* Seizure disorders
* Enlargement of the prostate gland with urinary retention (relative C.I.)
* Pheochromocytoma
* Pregnant and lactating women (relative C.I.)

Sibutramine side effects

In general, sibutramine is well-tolerated. The most common side effects have been constipation, inability to sleep, headache, and dry mouth. Other side effects include abdominal pain, acne, rash, chest pain, anxiety, joint pain, back pain, excitation, depression, sweating, dizziness, drowsiness, changes in taste, irregular or painful menstrual periods, flu-like syndrome, increased cough, muscle pain, nausea, vomiting, neck pain, nervousness, palpitations, tingling of the extremities, sore throat, and sinus congestion.
Abnormal liver tests have been reported in 1 in 60 persons who receive sibutramine.
Depression, psychosis, mania, suicidal thoughts and suicide have been reported rarely during treatment with sibutramine; however, it has not been established that sibutramine caused these events.  If any of these events occur during treatment, sibutramine probably should be discontinued.

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